The recent recovery of genomes for organisms from phyla with no isolated representative
(candidate phyla) via cultivation-independent genomics enabled delineation of major new …

Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Isoprenoid biosynthesis is essential for all living organisms, and isoprenoids are also of
industrial and agricultural interest. All isoprenoids are derived from prenyl diphosphate …

The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-
diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The …

When compared to other organisms, plants are atypical with respect to isoprenoid
biosynthesis: they utilize two distinct and separately compartmentalized pathways to build …

The Fourth Edition of Microbial Physiology retains the logical, easy-to-follow organization of
the previous editions. An introduction to cell structure and synthesis of cell components is …

Isoprenoids are a very diverse family of organic compounds widespread in the three
domains of life. Although they are produced from the condensation of the same precursors in …

Since the first introduction of the sulfa drugs and penicillin into clinical use, large numbers of
antibiotics have been developed and hence contributed to human health. But extensive use …

Engineering biosynthetic pathways in microbes for the production of complex chemicals and
pharmaceuticals is an attractive alternative to chemical synthesis. However, in transferring …

The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a
variety of signaling and transport proteins. Here we show that bacterial membranes contain …