Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been …

An epidemic of obesity has affected large portions of the world, increasing the risk of
develo** many different age-associated diseases, including cancer, cardiovascular …

Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …

Obesity is associated with metabolic disturbances that cause tissue stress and dysfunction.
Obese individuals are at a greater risk for chronic disease and often present with clinical …