Cardiac optogenetics: a decade of enlightenment
The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Simultaneous widefield voltage and dye-free optical map** quantifies electromechanical waves in human induced pluripotent stem cell-derived cardiomyocytes
Coupled electromechanical waves define a heart's function in health and diseases. Optical
map** of electrical waves using fluorescent labels offers mechanistic insights into cardiac …
map** of electrical waves using fluorescent labels offers mechanistic insights into cardiac …
COSMAS: a lightweight toolbox for cardiac optical map** analysis
Optical map** is widely used in experimental cardiology, as it allows visualization of
cardiac membrane potential and calcium transients. However, optical map** …
cardiac membrane potential and calcium transients. However, optical map** …
Neurohumoral cardiac regulation: Optogenetics gets into the groove
The cardiac autonomic nervous system (ANS) is the main modulator of heart function,
adapting contraction force, and rate to the continuous variations of intrinsic and extrinsic …
adapting contraction force, and rate to the continuous variations of intrinsic and extrinsic …
Novel optics-based approaches for cardiac electrophysiology: a review
Optical techniques for recording and manipulating cellular electrophysiology have advanced
rapidly in just a few decades. These developments allow for the analysis of cardiac cellular …
rapidly in just a few decades. These developments allow for the analysis of cardiac cellular …
From mice to mainframes: experimental models for investigation of the Intracardiac nervous system
The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the
heart, is involved in modulating many aspects of cardiac physiology. In recent years our …
heart, is involved in modulating many aspects of cardiac physiology. In recent years our …
Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP
EC Akerman, MJ Read, SJ Bose… - American Journal …, 2024 - journals.physiology.org
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive
stimulation of the inositol (1, 4, 5)-trisphosphate (IP3) signaling pathway has been linked to …
stimulation of the inositol (1, 4, 5)-trisphosphate (IP3) signaling pathway has been linked to …
Cardiac optogenetics: shining light on signaling pathways
S Leemann, F Schneider-Warme… - Pflügers Archiv-European …, 2023 - Springer
In the early 2000s, the field of neuroscience experienced a groundbreaking transformation
with the advent of optogenetics. This innovative technique harnesses the properties of …
with the advent of optogenetics. This innovative technique harnesses the properties of …
Extracellular matrix components halt peripheral nerve regeneration after myocardial infarction
26 Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) components
that are 27 involved in cell adhesion, growth and migration, especially in connective tissue …
that are 27 involved in cell adhesion, growth and migration, especially in connective tissue …