The immunology of B-1 cells: from development to aging
B-1 cells have intricate biology, with distinct function, phenotype and developmental origin
from conventional B cells. They generate a B cell receptor with conserved germline …
from conventional B cells. They generate a B cell receptor with conserved germline …
The role of B-1 cells in cancer progression and anti-tumor immunity
N Rodríguez-Zhurbenko, AM Hernández - Frontiers in Immunology, 2024 - frontiersin.org
In recent years, in addition to the well-established role of T cells in controlling or promoting
tumor growth, a new wave of research has demonstrated the active involvement of B cells in …
tumor growth, a new wave of research has demonstrated the active involvement of B cells in …
[HTML][HTML] Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Background Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest
cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors …
cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors …
Unraveling the complex interplay between anti-tumor immune response and autoimmunity mediated by B cells and autoantibodies in the era of anti-checkpoint …
S Soussan, G Pupier, I Cremer, PE Joubert… - Frontiers in …, 2024 - frontiersin.org
The intricate relationship between anti-tumor immunity and autoimmunity is a complex yet
crucial aspect of cancer biology. Tumor microenvironment often exhibits autoimmune …
crucial aspect of cancer biology. Tumor microenvironment often exhibits autoimmune …
[HTML][HTML] Natural antibodies drive type 2 immunity in response to damage-associated molecular patterns
Allergic airway disease (AAD) is an example of type 2 inflammation that leads to chronic
airway eosinophilia controlled by CD4 Th2 cells. Inflammation is reinforced by mast cells …
airway eosinophilia controlled by CD4 Th2 cells. Inflammation is reinforced by mast cells …
Reactivity graph yields interpretable IgM repertoire signatures as potential tumor biomarkers
Combining adaptive and innate immunity induction modes, the repertoire of immunoglobulin
M (IgM) can reflect changes in the internal environment including malignancies. Previously …
M (IgM) can reflect changes in the internal environment including malignancies. Previously …
Loss of B1 and marginal zone B cells during ovarian cancer
Recent advances in immunotherapy have not addressed the challenge presented by
ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has …
ovarian cancer. Although the peritoneum is an “accessible” locus for this disease there has …
Immune‐check blocking combination multiple cytokines shown curative potential in mice tumor model
H Su, H Geng, L Cai, M Xu, W **ng, W Long… - Cancer …, 2023 - Wiley Online Library
Objective In order to ensure the stable transcription of target genes, we constructed a
eukaryotic high expression vector carrying an immune‐check inhibitor PD‐1v and a variety …
eukaryotic high expression vector carrying an immune‐check inhibitor PD‐1v and a variety …
Identification of stromal cell proportion-related genes in the breast cancer tumor microenvironment using CorDelSFS feature selection: implications for tumor …
S Guo, Y Ma, X Li, W Li, X He, Z Yuan, Y Hu - Frontiers in Genetics, 2023 - frontiersin.org
Background: The tumor microenvironment (TME) of breast cancer (BRCA) is a complex and
dynamic micro-ecosystem that influences BRCA occurrence, progression, and prognosis …
dynamic micro-ecosystem that influences BRCA occurrence, progression, and prognosis …
[PDF][PDF] Immunogenicity Threshold in Allogeneic Cells Impacts CTL Response to Nondominant Congenic Antigens
Transplantation and cancer expose the immune system to neoantigens, including
immunogenic (dominant and subdominant) and nonimmunogenic Ags with varying …
immunogenic (dominant and subdominant) and nonimmunogenic Ags with varying …