The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Background Fibrosis is a tissue damage repair response caused by multiple pathogenic
factors which could occur in almost every apparatus and leading to the tissue structure …

Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …

Pancreatic islets are densely packed cellular aggregates containing various hormonal cell
types essential for blood glucose regulation. Interactions among these cells markedly affect …

The spatial organization of cells within a tissue is dictated throughout dynamic
developmental processes. We sought to understand whether cells geometrically coordinate …

Islet β-cell dedifferentiation is a key step in the progression of diabetes, and complement C3
enhances secretion of several inflammatory mediators and cytokines in type 2 diabetes …

The biomimetic pancreatic microenvironment improves the differentiation efficiency and
function of human embryonic stem cell-derived β-cells (S C-β cells). Thus, a laminin subunit …

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

Diabetes is a disease associated with the insufficiency of pancreatic endocrine part,
consisting mainly of pancreatic islets. Currently, diabetes is considered the fastest growing …

Missense variants are the most common type of coding genetic variants. Their functional
assessment is fundamental for defining any implication in human diseases and may also …