Mathematical modeling of tumor-immune cell interactions

GE Mahlbacher, KC Reihmer, HB Frieboes - Journal of Theoretical Biology, 2019 - Elsevier
The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

Hyperchaotic behaviors, optimal control, and synchronization of a nonautonomous cardiac conduction system

D Baleanu, SS Sajjadi, JH Asad, A Jajarmi… - Advances in Difference …, 2021 - Springer
In this paper, the hyperchaos analysis, optimal control, and synchronization of a
nonautonomous cardiac conduction system are investigated. We mainly analyze, control …

[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

S Bekisz, L Geris - Journal of Computational Science, 2020 - Elsevier
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

A new fractional model and optimal control of a tumor-immune surveillance with non-singular derivative operator

D Baleanu, A Jajarmi, SS Sajjadi… - … Interdisciplinary Journal of …, 2019 - pubs.aip.org
In this paper, we present a new fractional-order mathematical model for a tumor-immune
surveillance mechanism. We analyze the interactions between various tumor cell …

A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

C Gong, O Milberg, B Wang, P Vicini… - Journal of the …, 2017 - royalsocietypublishing.org
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …

A tumor–immune interaction model with the effect of impulse therapy

M Sardar, S Khajanchi, B Ahmad - Communications in Nonlinear Science …, 2023 - Elsevier
A mathematical model describing the growth of tumor cells and the effect of impulsive
therapy is studied in this paper. The governing equations and parameters related to the …

Circulating immune cell phenotype dynamics reflect the strength of tumor–immune cell interactions in patients during immunotherapy

JI Griffiths, P Wallet, LT Pflieger… - Proceedings of the …, 2020 - National Acad Sciences
The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor
immune activity prior to and early in cancer therapy is unclear. To address this question, we …

Mathematical modeling and computational prediction of cancer drug resistance

X Sun, B Hu - Briefings in bioinformatics, 2018 - academic.oup.com
Diverse forms of resistance to anticancer drugs can lead to the failure of chemotherapy.
Drug resistance is one of the most intractable issues for successfully treating cancer in …

[PDF][PDF] Mathematical modelling of COVID-19 disease dynamics: Interaction between immune system and SARS-CoV-2 within host

S Chowdhury, JT Chowdhury, SF Ahmed… - AIMS …, 2022 - researchgate.net
SARS-COV-2 (Coronavirus) viral growth kinetics within-host become a key fact to
understand the COVID-19 disease progression and disease severity since the year 2020 …

Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy

KJ Mahasa, L De Pillis, R Ouifki, A Eladdadi, P Maini… - Scientific reports, 2020 - nature.com
Mesenchymal stem cells (MSCs) loaded with oncolytic viruses are presently being
investigated as a new modality of advanced/metastatic tumors treatment and enhancement …