The airway epithelium: soldier in the fight against respiratory viruses
M Vareille, E Kieninger, MR Edwards… - Clinical microbiology …, 2011 - Am Soc Microbiol
The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …
physical barrier and through the mucociliary apparatus but also through its immunological …
The human immune response to respiratory syncytial virus infection
CD Russell, SA Unger, M Walton… - Clinical microbiology …, 2017 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is an important etiological agent of respiratory infections,
particularly in children. Much information regarding the immune response to RSV comes …
particularly in children. Much information regarding the immune response to RSV comes …
Respiratory viral infection alters the gut microbiota by inducing inappetence
Respiratory viral infections are extremely common, but their impacts on the composition and
function of the gut microbiota are poorly understood. We previously observed a significant …
function of the gut microbiota are poorly understood. We previously observed a significant …
Protective and harmful immunity to RSV infection
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …
Immunity to RSV in early-life
L Lambert, AM Sagfors, PJM Openshaw… - Frontiers in …, 2014 - frontiersin.org
Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology
CJ Pyle, FI Uwadiae, DP Swieboda, JA Harker - PLoS pathogens, 2017 - journals.plos.org
Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and
adaptive immune responses. In humans with respiratory virus infections, such as …
adaptive immune responses. In humans with respiratory virus infections, such as …
Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis
RJ Pickles, JP DeVincenzo - The Journal of pathology, 2015 - Wiley Online Library
Infants and young children with acute onset of wheezing and reduced respiratory airflows
are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie …
are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie …
Contribution of cytokines to tissue damage during human respiratory syncytial virus infection
The human respiratory syncytial virus (hRSV) remains one of the leading pathogens causing
acute respiratory tract infections (ARTIs) in children younger than 2 years old, worldwide …
acute respiratory tract infections (ARTIs) in children younger than 2 years old, worldwide …
Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity
Bronchiolitis is a leading cause of infant hospitalizations but its immunopathology remains
poorly understood. Here we present data from 244 infants hospitalized with bronchiolitis in a …
poorly understood. Here we present data from 244 infants hospitalized with bronchiolitis in a …
Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis
PS McNamara, BF Flanagan, CA Hart… - The Journal of …, 2005 - academic.oup.com
Background Respiratory syncytial virus (RSV) bronchiolitis in infants is characterized by a
massive neutrophilic infiltrate into the airways. Chemokines direct migration of leukocytes …
massive neutrophilic infiltrate into the airways. Chemokines direct migration of leukocytes …