Viruses are cellular parasites. The linkage between viral and host functions makes the study
of a viral life cycle an important key to cellular functions. A deeper understanding of many …

Advances in cryoEM and single-particle reconstruction have led to results at increasingly
high resolutions. However, to sustain continuing improvements in resolution it will be …

We present EMAN (Electron Micrograph ANalysis), a software package for performing
semiautomated single-particle reconstructions from transmission electron micrographs. The …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

A versatile tool for selecting particles from electron micrographs, intended for single particle
analysis and three-dimensional reconstruction, is presented. It is based on a local real …

Amethod is presented that reliably detects spherical viruses from a wide variety of noisy low-
contrast electron micrographs. Such detection is one of the first image analysis steps in the …

Manual selection of single particles in images acquired using cryo-electron microscopy
(cryoEM) will become a significant bottleneck when a very large number of images are …

A new computational method for the detection of virus particles in transmission electron
microscopy (TEM) images is presented. Our approach is to use a convolutional neural …

Accurate and automatic particle detection from cryo-electron microscopy (cryo-EM images)
is very important for high-resolution reconstruction of large macromolecular structures. In this …

Recent progress in single-particle reconstruction methods and cryo-EM techniques has led
to the determination of macromolecular structures with unprecedented resolution. The …