Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …
thiazolidinones being a widely studied class of small molecules used in modern organic and …
Thiazole-pyrazoline hybrids as potential antimicrobial agent: Synthesis, biological evaluation, molecular docking, DFT studies and POM analysis
In this study, an efficient synthesis of new thiazole-pyrazoline hybrids was investigated and
hybrids were screened for their antimicrobial activities against four species of pathogenic …
hybrids were screened for their antimicrobial activities against four species of pathogenic …
Recent developments with rhodanine as a scaffold for drug discovery
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …
privileged heterocycles in medicinal chemistry. The main achievements include the …
Thiazole-bearing 4-thiazolidinones as new anticonvulsant agents
M Mishchenko, S Shtrygol, D Kaminskyy… - Scientia Pharmaceutica, 2020 - mdpi.com
Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids
based on 2-imino-4-thiazolidinone and 2, 4-dioxothiazolidine-5-carboxylic acid cores. The …
based on 2-imino-4-thiazolidinone and 2, 4-dioxothiazolidine-5-carboxylic acid cores. The …
Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets
YM Liu, K Nepali, JP Liou - Journal of medicinal chemistry, 2017 - ACS Publications
Idiopathic pulmonary fibrosis (IPF), a chronic and progressive fibrosing interstitial
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …
Diversity-oriented synthesis of spiropyrrolo [1, 2-a] isoquinoline derivatives via diastereoselective and regiodivergent three-component 1, 3-dipolar cycloaddition …
A Toumi, S Boudriga, K Hamden, I Daoud… - The Journal of …, 2021 - ACS Publications
An efficient diastereoselective route is developed to get access to novel spiropyrrolo [1, 2-a]
isoquinoline-oxindole skeletons by a one-pot three-component [3+ 2] cycloaddition reaction …
isoquinoline-oxindole skeletons by a one-pot three-component [3+ 2] cycloaddition reaction …
Thiazolidinone/thiazole based hybrids–New class of antitrypanosomal agents
Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
Synthesis, biological evaluation and docking study of 1, 3, 4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX
Selective inhibition of both cyclooxygenase-2 (COX-2) and 15-lipooxygenase (15-LOX) may
provide good strategy for alleviation of inflammatory disorders while minimizing side effects …
provide good strategy for alleviation of inflammatory disorders while minimizing side effects …
Study of novel anticancer 4-thiazolidinone derivatives
Thiazolidinones are a known class of prospective drug-like molecules, especially in the
design of new anticancer agents. Two of the most prominent subtypes of these compounds …
design of new anticancer agents. Two of the most prominent subtypes of these compounds …