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The cerebellum, sensitive periods, and autism
Cerebellar research has focused principally on adult motor function. However, the
cerebellum also maintains abundant connections with nonmotor brain regions throughout …
cerebellum also maintains abundant connections with nonmotor brain regions throughout …
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
Significant progress has been made in understanding the pre-symptomatic phase of
amyotrophic lateral sclerosis. While much is still unknown, advances in other …
amyotrophic lateral sclerosis. While much is still unknown, advances in other …
[HTML][HTML] Patient satisfaction with health care services; an application of physician's behavior as a moderator
Patient satisfaction is a measure of the extent to which a patient is content with the health
care they received from their health care provider. Patient satisfaction is one of the most …
care they received from their health care provider. Patient satisfaction is one of the most …
[HTML][HTML] Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE …
Spinal muscular atrophy (SMA) is a neurodegenerative disease associated with severe
muscle atrophy and weakness in the limbs and trunk. We report interim efficacy and safety …
muscle atrophy and weakness in the limbs and trunk. We report interim efficacy and safety …
Safety and efficacy of risdiplam in patients with type 1 spinal muscular atrophy (FIREFISH part 2): secondary analyses from an open-label trial
Background Risdiplam is an orally administered therapy that modifies pre-mRNA splicing of
the survival of motor neuron 2 (SMN2) gene and is approved for the treatment of spinal …
the survival of motor neuron 2 (SMN2) gene and is approved for the treatment of spinal …
Malformations of cortical development: clinical features and genetic causes
Malformations of cortical development are common causes of developmental delay and
epilepsy. Some patients have early, severe neurological impairment, but others have …
epilepsy. Some patients have early, severe neurological impairment, but others have …
Genetic basis of brain malformations
Malformations of cortical development (MCD) represent a major cause of developmental
disabilities, severe epilepsy, and reproductive disadvantage. Genes that have been …
disabilities, severe epilepsy, and reproductive disadvantage. Genes that have been …
Clinical trial and postmarketing safety of onasemnogene abeparvovec therapy
Introduction This is the first description of safety data for intravenous onasemnogene
abeparvovec, the only approved systemically administered gene-replacement therapy for …
abeparvovec, the only approved systemically administered gene-replacement therapy for …
An integrated safety analysis of infants and children with symptomatic spinal muscular atrophy (SMA) treated with nusinersen in seven clinical trials
Background Treatment with nusinersen has demonstrated significant and clinically
meaningful benefits in clinical trials in infants and children with spinal muscular atrophy …
meaningful benefits in clinical trials in infants and children with spinal muscular atrophy …
[HTML][HTML] Epileptic multi-seizure type classification using electroencephalogram signals from the Temple University Hospital Seizure Corpus: A review
Epilepsy is one of the most paramount neurological diseases, affecting about 1% of the
world's population. Seizure detection and classification are difficult tasks and are ongoing …
world's population. Seizure detection and classification are difficult tasks and are ongoing …