Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes in macrophage phenotype and …

The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Macrophages populate every organ during homeostasis and disease, displaying features of
tissue imprinting and heterogeneous activation. The disconnected picture of macrophage …

Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired
pneumonia. As phagocytosis by macrophages plays a critical role in the control of bacteria …