Potency of Xanthone Derivatives from Garcinia mangostana L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A …
ACE2 and Mpro in the pathology of SARS-CoV-2 show great potential in develo** COVID-
19 drugs as therapeutic targets, due to their roles as the “gate” of viral entry and viral …
19 drugs as therapeutic targets, due to their roles as the “gate” of viral entry and viral …
Design, synthesis, in vitro α-glucosidase inhibition, docking, and molecular dynamics of new phthalimide-benzenesulfonamide hybrids for targeting type 2 diabetes
In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives
4a–n were synthesized, and their inhibitory activity against yeast α-glucosidase was …
4a–n were synthesized, and their inhibitory activity against yeast α-glucosidase was …
Identification of new pharmacophore against SARS-CoV-2 spike protein by multi-fold computational and biochemical techniques
COVID-19 appeared as a highly contagious disease after its outbreak in December 2019 by
the virus, named SARS-CoV-2. The threat, which originated in Wuhan, China, swiftly …
the virus, named SARS-CoV-2. The threat, which originated in Wuhan, China, swiftly …
Targeting papain-like protease by natural products as novel therapeutic potential SARS-CoV-2
The highly infectious respiratory illness 'COVID-19'was caused by SARS-CoV-2 and is
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …
Multi-Fold Computational Analysis to Discover Novel Putative Inhibitors of Isethionate Sulfite-Lyase (Isla) from Bilophila wadsworthia: Combating Colorectal Cancer …
Simple Summary Hydrogen sulfide (H2S) has been produced by certain gut bacteria and
associated with the development of inflammatory bowel disease (IBD) and colon cancer …
associated with the development of inflammatory bowel disease (IBD) and colon cancer …
Synthesis, identification, computer-aided docking studies, and ADMET prediction of novel benzimidazo-1, 2, 3-triazole based molecules as potential antimicrobial …
2-azido-1 H-benzo [d] imidazole derivatives 1a, b were reacted with a β-ketoester such as
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
acetylacetone in the presence of sodium ethoxide to obtain the desired molecules 2a, b. The …
Crystal Structures of Coronaviral Main Proteases in Complex with the non-covalent inhibitor X77
H Jiang, W Li, X Zhou, J Zhang, J Li - International Journal of Biological …, 2024 - Elsevier
Main proteases (M pro s) are a class of conserved cysteine hydrolases among
coronaviruses and play a crucial role in viral replication. Therefore, M pro s are ideal targets …
coronaviruses and play a crucial role in viral replication. Therefore, M pro s are ideal targets …
Synthesis, biological evaluation and molecular modeling studies of methyl indole-isoxazole carbohydrazide derivatives as multi-target anti-Alzheimer's agents
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects the
elderly population globally and there is an urgent demand for develo** novel anti-AD …
elderly population globally and there is an urgent demand for develo** novel anti-AD …
Evaluation of apigenin-based biflavonoid derivatives as potential therapeutic agents against viral protease (3CLpro) of SARS-CoV-2 via molecular docking, molecular …
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of the pandemic COVID-19 disease that affects human respiratory function. Despite …
agent of the pandemic COVID-19 disease that affects human respiratory function. Despite …
[Retracted] Identification of Potential Poly (ADP‐Ribose) Polymerase‐1 Inhibitors Derived from Rauwolfia serpentina: Possible Implication in Cancer Therapy
AM Abuzenadah, F Al-Sayes… - Evidence‐Based …, 2022 - Wiley Online Library
Poly (ADP‐ribose) polymerase‐1 (PARP‐1) has been recognized as a prospective target for
the development of novel cancer therapeutics. Several PARP‐1 inhibitors are currently …
the development of novel cancer therapeutics. Several PARP‐1 inhibitors are currently …