Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …
Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Post-translational modifications of intermediate filament proteins: mechanisms and functions
NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …
Types I and II keratin intermediate filaments
Keratins—types I and II—are the intermediate-filament-forming proteins expressed in
epithelial cells. They are encoded by 54 evolutionarily conserved genes (28 type I, 26 type …
epithelial cells. They are encoded by 54 evolutionarily conserved genes (28 type I, 26 type …
Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells
Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial
tissues in a site-specific and differentiation-dependent manner. The complex network of …
tissues in a site-specific and differentiation-dependent manner. The complex network of …
Intermediate filaments at the junction of mechanotransduction, migration, and development
R Sanghvi-Shah, GF Weber - Frontiers in cell and developmental …, 2017 - frontiersin.org
Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …
actively transduce and respond to mechanical signals and their internal architecture must …
The expanding significance of keratin intermediate filaments in normal and diseased epithelia
Intermediate filaments are assembled from a diverse group of evolutionary conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …
proteins and are specified in a tissue-dependent, cell type-dependent, and context …
Pathophysiology of NAFLD and NASH in experimental models: the role of food intake regulating peptides
L Kořínková, V Pražienková, L Černá… - Frontiers in …, 2020 - frontiersin.org
Obesity, diabetes, insulin resistance, sedentary lifestyle, and Western diet are the key factors
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …
Networking galore: intermediate filaments and cell migration
Intermediate filaments (IFs) are assembled from a diverse group of evolutionarily conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …
proteins and are specified in a tissue-dependent, cell type-dependent, and context …
Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia
R Windoffer, M Beil, TM Magin, RE Leube - Journal of Cell Biology, 2011 - rupress.org
Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …