▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

The mechanisms involved in prion neurotoxicity are unclear, and therapies preventing
accumulation of PrPSc, the disease-associated form of prion protein (PrP), do not …

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru
decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions …

Summary Background Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion
encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo …

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-
resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition …

The transmissible spongiform encephalopathies (TSEs) are fatal, neurodegenerative
diseases for which no effective treatments are available. The likelihood that a bovine form of …

Cerebral deposition of β-amyloid is a major neuropathological feature in Alzheimer's
disease. Here we show that tetracyclines, tetracycline and doxycycline, classical antibiotics …

Knowledge about the systemic amyloidoses has increased considerably during the last few
years. This group of diseases is characterized by great biochemical variability, including at …

We report that branched polyamines, including polyamidoamide dendimers,
polypropyleneimine, and polyethyleneimine, are able to purge PrPSc, the protease-resistant …