Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota

Y Zhang, P Tan, Y Zhao, X Ma - Gut Microbes, 2022 - Taylor & Francis
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and
travelers in develo** countries. ETEC is characterized by the ability to produce major …

Non-canonical inflammasome activation targets caspase-11

N Kayagaki, S Warming, M Lamkanfi, LV Walle… - Nature, 2011 - nature.com
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-
binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is …

Noncanonical inflammasome activation by intracellular LPS independent of TLR4

N Kayagaki, MT Wong, IB Stowe, SR Ramani… - Science, 2013 - science.org
Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella
typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular …

[HTML][HTML] Cytoplasmic vacuolization in cell death and survival

AV Shubin, IV Demidyuk, AA Komissarov, LM Rafieva… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …

From lectin structure to functional glycomics: principles of the sugar code

HJ Gabius, S André, J Jiménez-Barbero… - Trends in biochemical …, 2011 - cell.com
Lectins are carbohydrate-binding proteins which lack enzymatic activity on their ligand and
are distinct from antibodies and free mono-and oligosaccharide sensor/transport proteins …

Endoplasmic reticulum stress: its role in disease and novel prospects for therapy

AH Schönthal - Scientifica, 2012 - Wiley Online Library
The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

GRP78 targeting: Hitting two birds with a stone

AA Elfiky, AM Baghdady, SA Ali, MI Ahmed - Life sciences, 2020 - Elsevier
Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …

[HTML][HTML] Protein selection and export via outer membrane vesicles

KE Bonnington, MJ Kuehn - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Outer membrane vesicles (OMVs) are constitutively produced by all Gram-negative bacteria.
OMVs form when buds from the outer membrane (OM) of cells encapsulate periplasmic …

[HTML][HTML] Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome

JM Platnich, H Chung, A Lau, CF Sandall… - Cell reports, 2018 - cell.com
The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by
intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways …