Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and
travelers in develo** countries. ETEC is characterized by the ability to produce major …
travelers in develo** countries. ETEC is characterized by the ability to produce major …
Non-canonical inflammasome activation targets caspase-11
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-
binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is …
binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is …
Noncanonical inflammasome activation by intracellular LPS independent of TLR4
N Kayagaki, MT Wong, IB Stowe, SR Ramani… - Science, 2013 - science.org
Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella
typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular …
typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular …
[HTML][HTML] Cytoplasmic vacuolization in cell death and survival
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …
From lectin structure to functional glycomics: principles of the sugar code
HJ Gabius, S André, J Jiménez-Barbero… - Trends in biochemical …, 2011 - cell.com
Lectins are carbohydrate-binding proteins which lack enzymatic activity on their ligand and
are distinct from antibodies and free mono-and oligosaccharide sensor/transport proteins …
are distinct from antibodies and free mono-and oligosaccharide sensor/transport proteins …
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy
AH Schönthal - Scientifica, 2012 - Wiley Online Library
The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …
calcium storage, and protein folding and processing. A number of physiological and …
GRP78 targeting: Hitting two birds with a stone
AA Elfiky, AM Baghdady, SA Ali, MI Ahmed - Life sciences, 2020 - Elsevier
Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
[HTML][HTML] Protein selection and export via outer membrane vesicles
Outer membrane vesicles (OMVs) are constitutively produced by all Gram-negative bacteria.
OMVs form when buds from the outer membrane (OM) of cells encapsulate periplasmic …
OMVs form when buds from the outer membrane (OM) of cells encapsulate periplasmic …
[HTML][HTML] Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome
JM Platnich, H Chung, A Lau, CF Sandall… - Cell reports, 2018 - cell.com
The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by
intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways …
intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways …