The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …

More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides
that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs …

Antimicrobial host defense peptides are produced by all complex organisms as well as
some microbes and have diverse and complex antimicrobial activities. Collectively these …

Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental
cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Due to difficulties in cell culture propagation, the mechanisms of hepatitis C virus (HCV)
entry are poorly understood. Here, postbinding cellular mechanisms of HCV entry were …

In contrast to a detailed understanding of antiviral cellular immune responses, the impact of
neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis …