[HTML][HTML] Design of experiments (DoE) applied to pharmaceutical and analytical quality by design (QbD)

IM Fukuda, CFF Pinto, CS Moreira… - Brazilian journal of …, 2018 - SciELO Brasil
According to Quality by Design (QbD) concept, quality should be built into product/method
during pharmaceutical/analytical development. Usually, there are many input factors that …

Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …

TQM, SCM and operational performance: an empirical study of Indian pharmaceutical industry

S Sharma, S Modgil - Business Process Management Journal, 2020 - emerald.com
Purpose The purpose of this paper is to investigate the impact of total quality management
(TQM) and supply chain management (SCM) practices on operational performance, and …

[HTML][HTML] Question-based review for pharmaceutical development: An enhanced quality approach

A Simões, F Veiga, C Vitorino - European Journal of Pharmaceutics and …, 2024 - Elsevier
Over the last years, the pharmaceutical industry has faced real challenges regarding quality
assurance. In this context, the establishment of more holistic approaches to the …

Development and optimization of liquid chromatography analytical methods by using AQbD principles: Overview and recent advances

T Tome, N Žigart, Z Časar… - Organic process research …, 2019 - ACS Publications
This review presents the Analytical Quality by Design (AQbD) concept, an extension of
Quality by Design (QbD), which was introduced in 2004 by the US Food and Drug …

Systematic screening of pharmaceutical polymers for hot melt extrusion processing: A comprehensive review

R Thakkar, R Thakkar, A Pillai, EA Ashour… - International journal of …, 2020 - Elsevier
Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

Quality by design (QbD) approaches in current pharmaceutical set-up

V Mishra, S Thakur, A Patil, A Shukla - Expert opinion on drug …, 2018 - Taylor & Francis
ABSTRACT Introduction: Quality by design (QbD) encourages the pharmaceutical industry
to use risk management and science-based manufacturing principles to gain process and …

[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

New trends in the quality control of enantiomeric drugs: quality by design-compliant development of chiral capillary electrophoresis methods

S Orlandini, G Hancu, ZI Szabó, A Modroiu, LA Papp… - Molecules, 2022 - mdpi.com
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is
commonly used in the enantioseparation and chiral purity control of pharmaceuticals from …

Drilling into “Quality by Design” approach for analytical methods

L Chiarentin, C Gonçalves, C Augusto… - Critical Reviews in …, 2024 - Taylor & Francis
The need for consistency in analytical method development reinforces the dependence of
pharmaceutical product development and manufacturing on robust analytical data. The …