Neuronal nicotinic receptors: from structure to pathology

C Gotti, F Clementi - Progress in neurobiology, 2004 - Elsevier
Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Neuronal nicotinic receptors in the human brain

D Paterson, A Nordberg - Progress in neurobiology, 2000 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

R Freedman, M Hall, LE Adler, S Leonard - Biological psychiatry, 1995 - Elsevier
This study tests the hypothesis that nicotinic cholinergic receptors, including those sensitive
to the antagonist α-bungarotoxin, are decreased in the hippocampus of schizophrenics. The …

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

R Freedman, H Coon… - Proceedings of the …, 1997 - National Acad Sciences
Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli
was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in …

Schizophrenia, sensory gating, and nicotinic receptors

LE Adler, A Olincy, M Waldo, JG Harris… - Schizophrenia …, 1998 - academic.oup.com
A series of human and animal investigations has suggested that altered expression and
function of the α7-nicotinic cholinergic receptor may be responsible for the auditory sensory …

Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications

A Nordberg - Biological psychiatry, 2001 - Elsevier
The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for
functional processes, including cognitive and memory functions. The nAChRs acting as …

Human neuronal nicotinic receptors

C Gotti, D Fornasari, F Clementi - Progress in neurobiology, 1997 - Elsevier
Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative,
behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine …

Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

LF Martin, WR Kem, R Freedman - Psychopharmacology, 2004 - Springer
Rationale and objective Auditory sensory gating, a biological measurement of the ability to
suppress the evoked response to the second of two auditory stimuli, is diminished in people …

Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain

EK Perry, MLW Lee, CM Martin-Ruiz… - American Journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: Measures of cholinergic transmitter activity were investigated in patients with
autism because of reported neuropathological abnormalities in cholinergic nuclei in the …

Nicotinic receptor abnormalities in the cerebellar cortex in autism

M Lee, C Martin‐Ruiz, A Graham, J Court, E Jaros… - Brain, 2002 - academic.oup.com
Autism is a common developmental disorder associated with structural and inferred
neurochemical abnormalities of the brain. Cerebellar abnormalities frequently have been …