Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The toxicity of amyloid‐forming proteins is correlated with their interactions with cell
membranes. Binding events between amyloidogenic proteins and membranes result in …

Disruption of cell membranes by Aβ is believed to be one of the key components of Aβ
toxicity. However, the mechanism by which this occurs is not fully understood. Here, we …

An increasing number of cases where amyloids of different proteins are found in the same
patient are being reported. This observation complicates diagnosis and clinical intervention …

In this review, we elucidate the mechanisms of A β oligomer toxicity which may contribute to
Alzheimer's disease (AD). In particular, we discuss on the interaction of A β oligomers with …

Amyloid β proteins and oxidative stress are believed to have central roles in the
development of Alzheimer's disease. Lipid membranes are among the most vulnerable …

The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's
disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid β …

Brain cholesterol plays a critical role in Alzheimer's disease and other neurodegenerative
diseases. The molecular mechanisms linking cholesterol to neurotoxicity have remained …

Aβ oligomers cause a collection of molecular events associated with memory loss in
Alzheimer's disease, centering on disrupting the maintenance of synapse structure and …