[HTML][HTML] Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections
Live attenuated vaccines could have beneficial, non-specific effects of protecting against
vaccine-unrelated infections, such as BCG protecting against respiratory infection. During …
vaccine-unrelated infections, such as BCG protecting against respiratory infection. During …
[HTML][HTML] Trained immunity: implications for vaccination
Highlights•Trained immunity is induced in a variety of innate immune cell types.•Central and
peripheral trained immunity underlies the long-term effects of innate immunity.•Metabolic …
peripheral trained immunity underlies the long-term effects of innate immunity.•Metabolic …
Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a …
SY Tartof, JM Slezak, L Puzniak, V Hong… - The Lancet …, 2022 - thelancet.com
Background The duration of protection against the omicron (B. 1.1. 529) variant for current
COVID-19 vaccines is not well characterised. Vaccine-specific estimates are especially …
COVID-19 vaccines is not well characterised. Vaccine-specific estimates are especially …
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
Trained immunity: Target for prophylaxis and therapy
Trained immunity is a de facto memory for innate immune responses, leading to long-term
functional reprogramming of innate immune cells. In physiological conditions, trained …
functional reprogramming of innate immune cells. In physiological conditions, trained …
The role of trained immunity in COVID-19: Lessons for the next pandemic
Trained immunity is a long-term increase in responsiveness of innate immune cells, induced
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections
The innate immune system is able to build memory-like features in response to certain
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
Functional and epigenetic changes in monocytes from adults immunized with an AS01-adjuvanted vaccine
V Bechtold, KK Smolen, W Burny… - Science Translational …, 2024 - science.org
The adjuvant AS01 plays a key role in the immunogenicity of several approved human
vaccines with demonstrated high efficacy. Its adjuvant effect relies on activation of the innate …
vaccines with demonstrated high efficacy. Its adjuvant effect relies on activation of the innate …
Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave
COVID-19 remains a stark health threat worldwide, in part because of minimal levels of
targeted vaccination outside high-income countries and highly transmissible variants …
targeted vaccination outside high-income countries and highly transmissible variants …
Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants
Highlights•Studies suggest adjuvants could induce epigenetic reprogramming of myeloid
cells.•Reprogramming could lead to a durable state of heightened antiviral resistance.•This …
cells.•Reprogramming could lead to a durable state of heightened antiviral resistance.•This …