Advancements in omics and breakthrough gene therapies: a glimpse into the future of peripheral artery disease
PG Brennan, L Mota, T Aridi, N Patel, P Liang… - Annals of Vascular …, 2024 - Elsevier
Highlights•Multiomics analyses to study peripheral artery disease and therapeutic gene
targets.•Gene therapy strategies targeting pathogenic hubs to treat peripheral artery …
targets.•Gene therapy strategies targeting pathogenic hubs to treat peripheral artery …
Endothelial cell (EC)-specific CTGF/CCN2 Expression Increases EC Reprogramming and Atherosclerosis
F Li, S Kumar, A Pokutta-Paskaleva, D Kang, C Kim… - Matrix Biology, 2025 - Elsevier
Arterial endothelial cells (ECs) reside in a complex biomechanical environment. ECs sense
and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of …
and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of …
Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues
RM Gorashi, T Baddour, SJ Chittle, NEF Velez… - bioRxiv, 2024 - biorxiv.org
Aortic valve stenosis (AVS) is a progressive disease wherein males develop valve
calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) …
calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) …