Understanding the relationship between genetic variation and biological function on a
genomic scale is expected to provide fundamental new insights into the biology, evolution …

The development and use of molecular markers for the detection and exploitation of DNA
polymorphism is one of the most significant developments in the field of molecular genetics …

Three-dimensional cell and organoid cultures rely on the mechanical support of viscoelastic
matrices. However, commonly used matrix materials lack control over key cell-instructive …

We developed OligoCalc as a web-accessible, client-based computational engine for
reporting DNA and RNA single-stranded and double-stranded properties, including …

This paper demonstrated for the first time a simple wet-chemical strategy for synthesizing
hemin− graphene hybrid nanosheets (H-GNs) through the π− π interactions. Significantly …

Summary A clone encoding PrP 27-30, the major protein in purifled preparations of scrapie
agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide …

Allelic sequence variation has been analysed by synthetic oligonucleotide hybridization
probes which can detect single base substitutions in human genomic DNA1–3. An allele …

A point mutation in the simian virus 40 large-T gene, which was generated by mixed
oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a …

Rapid access to genetic information is central to the revolution taking place in molecular
genetics. The simultaneous analysis of the entire human mitochondrial genome is described …

Thermodynamics of 39 oligonucleotides with internal G⊙ T mismatches dissolved in 1 M
NaCl were determined from UV absorbance versus temperature profiles. These data were …