Tuberculosis (TB) is among the top 10 leading causes of death in low-income countries.
Statistically, TB kills more than 30,000 people each week and leads to more deaths than any …

Macrophages are the preeminent phagocytic cells which control multiple infections.
Tuberculosis a leading cause of death in mankind and the causative organism …

Mycobacterium tuberculosis (Mtb) continues to pose a significant threat to global health
because it causes granulomas and systemic inflammatory responses during active …

Autophagy is a conserved stress response mechanism that occurs in eukaryotes. It involves
the degradation of various cargoes (eg, damaged organelles, misfolded proteins, etc.) within …

MicroRNA-mediated metabolic reprogramming recently has been identified as an important
strategy for Mycobacterium tuberculosis (Mtb) to evade host immune responses. However, it …

Inflammatory pathways involving Mesenchymal stromal cells (MSCs) play an important role
in Mycobacterium tuberculosis (Mtb) infection. H37Rv (Rv) is a standard virulent strain …

Pyroptosis is a host immune strategy to defend against Mycobacterium tuberculosis (Mtb)
infection. S100A4, a calcium-binding protein that plays an important role in promoting …

Cholesterol is a key carbon source for Mycobacterium tuberculosis (Mtb) survival and
persistence within macrophages. However, little is known about the role of cholesterol …

During mycobacterial infections, pathogenic mycobacteria manipulate both host immune
and stromal cells to establish and maintain a productive infection. In humans, non-human …

Autophagy plays a vital role in eliminating intracellular mycobacterium. It is regulated by
multiple metabolic processes including glutaminolysis. Glutaminase 1 (GLS1) is the rate …