Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused more than 6.3
million deaths to date. Despite great efforts to curb the spread of severe acute respiratory …

Classically, osteoclast fusion consists of four basic steps:(1) attraction/migration,(2)
recognition,(3) cell–cell adhesion, and (4) membrane fusion. In theory, this sounds like a …

Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of
representative reference panels, thus hindering the discovery of ancestry-specific variants …

Background Acute bone loss after fracture is associated with various effects on the complete
recovery process and a risk of secondary fractures among patients. Studies have reported …

Abstract Purpose of Review Atypical femur fractures (AFFs) are rare subtrochanteric or
diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …

Osteoporosis (OP) is a bone disease which affects a number of post‐menopausal females
and puts many at risk for fractures. A large number of patients are taking bisphosphonates …

Age related changes to the skeleton, such as osteoporosis, increase the risk of fracture and
morbidity in the elderly population. In osteoporosis, bone remodeling becomes unbalanced …

Several small genetic association studies have been conducted for atypical femur fracture
(AFF) without replication of results. We assessed previously implicated and novel genes …

Acute myeloid leukemia (AML) is a rare aggressive blood cancer without any long-term cure.
Further, due to the extreme molecular heterogeneity of the disease, drug treatment response …