Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
[HTML][HTML] Dry powder for pulmonary delivery: A comprehensive review
B Chaurasiya, YY Zhao - Pharmaceutics, 2021 - mdpi.com
The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …
treatment. It possesses several advantages, which can be categorized into physiological, ie …
Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation
Despite lipid nanoparticles'(LNPs) success in the effective and safe delivery of mRNA
vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs …
vaccines, an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs …
Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study
YG Zhu, M Shi, A Monsel, C Dai, X Dong… - Stem cell research & …, 2022 - Springer
Background Existing clinical studies supported the potential efficacy of mesenchymal
stromal cells as well as derived exosomes in the treatment of COVID-19. We aimed to …
stromal cells as well as derived exosomes in the treatment of COVID-19. We aimed to …
Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles
M Shi, Q Yang, A Monsel, J Yan, C Dai… - Journal of …, 2021 - Wiley Online Library
Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) turn out to be a
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …
Inhalation drug delivery devices: technology update
The pulmonary route of administration has proven to be effective in local and systemic
delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non …
delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non …
[HTML][HTML] Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines
Y Guo, H Bera, C Shi, L Zhang, D Cun… - Acta Pharmaceutica Sinica …, 2021 - Elsevier
Pulmonary administration route has been extensively exploited for the treatment of local
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …
Delivery strategies for sustained drug release in the lungs
C Loira-Pastoriza, J Todoroff, R Vanbever - Advanced drug delivery reviews, 2014 - Elsevier
Drug delivery to the lungs by inhalation offers a targeted drug therapy for respiratory
diseases. However, the therapeutic efficacy of inhaled drugs is limited by their rapid …
diseases. However, the therapeutic efficacy of inhaled drugs is limited by their rapid …
[HTML][HTML] Particle engineering in dry powders for inhalation
R Scherließ, S Bock, N Bungert, A Neustock… - European Journal of …, 2022 - Elsevier
Drug administration by inhalation is a well-established approach to treat respiratory and
systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an …
systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an …
[HTML][HTML] Recent advances in aerosolised drug delivery
Pulmonary route is extensively studied for the diagnosis and treatment of pulmonary and
extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and …
extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and …