The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process
where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit …

In this Review, we describe the pathogenesis, diagnosis and management of primary
hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a …

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Bone tissue engineering is an exciting approach to directly repair bone defects or engineer
bone tissue for transplantation. Biomaterials play a pivotal role in providing a template and …

The composition of a bone can be described in terms of the mineral phase, hydroxyapatite,
the organic phase, which consists of collagen type I, noncollagenous proteins, other …

Background Parathyroid hormone increases bone strength primarily by stimulating bone
formation, whereas antiresorptive drugs reduce bone resorption. We conducted a …

Objective To compare the bone anabolic drug teriparatide (20 μg/day) with the antiresorptive
drug alendronate (10 mg/day) for treating glucocorticoid‐induced osteoporosis (OP) …

MicroComputed Tomography has become the gold standard for studying 3D microscopic
structures nondestructively, and this book provides up-to-date coverage of the modality. The …

All therapies currently recommended for the management of osteoporosis act mainly to
inhibit bone resorption and reduce bone remodeling. PTH and its analog, teriparatide …