Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …

Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating
mutations in the KRAS oncogene. However, PDA mouse models show that mutant Kras …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

With 5-year survival rates remaining constant at 6% and rising incidences associated with
an epidemic in obesity and metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) …

Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually
exclusive with the presence of K-RAS oncogenes in lung and colon tumors. We have …

Background & Aims Pancreatitis is the most important risk factor for pancreatic ductal
adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process …

Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT
mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a …

Mutation of the KRAS oncogene in pancreatic cancer is responsible for permanent activation
of the P21 RAS protein and the cascade of signalling pathways. Consequently, multiple …