CFD simulation of stirred tanks: Comparison of turbulence models. Part I: Radial flow impellers
A critical review of the published literature regarding the computational fluid dynamics (CFD)
modelling of single‐phase turbulent flow in stirred tank reactors is presented. In this part of …
modelling of single‐phase turbulent flow in stirred tank reactors is presented. In this part of …
A general review of the current development of mechanically agitated vessels
The mixing process in a mechanically agitated vessel is a widespread phenomenon which
plays an important role among industrial processes. In that process, one of the crucial …
plays an important role among industrial processes. In that process, one of the crucial …
[HTML][HTML] Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation
With reaction timescales equal to or shorter than the circulation time, the ideal mixing
assumption typically does not hold for large scale bioreactors. As a consequence large …
assumption typically does not hold for large scale bioreactors. As a consequence large …
Scale-up of aerated bioreactors: CFD validation and application to the enzyme production by Trichoderma reesei
Abstract The application of Computational Fluid Dynamics to aerobic fermentations faces
several issues, such as validation of multiphase models at high gas holdup and with …
several issues, such as validation of multiphase models at high gas holdup and with …
Experimental and CFD physical characterization of animal cell bioreactors: from micro-to production scale
Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is
a delicate task, frequently leading to different conditions across scales. To provide a more …
a delicate task, frequently leading to different conditions across scales. To provide a more …
CFD simulation of stirred tanks: Comparison of turbulence models (Part II: Axial flow impellers, multiple impellers and multiphase dispersions)
In the first part of the review, published literature regarding the CFD modelling of single‐
phase turbulent flow in stirred tank reactors with radial flow impellers was critically analysed …
phase turbulent flow in stirred tank reactors with radial flow impellers was critically analysed …
Evaluation of mixing and mass transfer in a stirred pilot scale bioreactor utilizing CFD
Abstract Knowledge and prediction of mixing and mass transfer in agitated bioreactors is
fundamental for process development and scale up. In particular key process parameters …
fundamental for process development and scale up. In particular key process parameters …
Study on hydrodynamics characteristics in a gas-liquid stirred tank with a self-similarity impeller based on CFD-PBM coupled model
D Gu, L Wen, H Xu, M Ye - Journal of the Taiwan Institute of Chemical …, 2023 - Elsevier
Background In general, radial impeller has been the most widely employed for the gas-liquid
mixing process in the stirred tank. However, gas cavities are easy to form behind the …
mixing process in the stirred tank. However, gas cavities are easy to form behind the …
Multidimensional population balance model for the simulation of turbulent gas–liquid systems in stirred tank reactors
The prediction of turbulent gas–liquid systems, and in general of multiphase flows, has been
historically performed with the implicit assumption of separately considering fluid dynamics …
historically performed with the implicit assumption of separately considering fluid dynamics …
Development of a scale-up strategy for an aerated coaxial mixer containing a non-Newtonian fluid: A mass transfer approach
Coaxial mixers have been shown to be effective in enhancing the hydrodynamic stress and
shear environment inside the aerated systems. However, the scale-up study of the aerated …
shear environment inside the aerated systems. However, the scale-up study of the aerated …