Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development

H Yu, O Alkhamis, J Canoura, Y Liu… - Angewandte Chemie …, 2021 - Wiley Online Library
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

Real-Time, In Vivo Molecular Monitoring Using Electrochemical Aptamer Based Sensors: Opportunities and Challenges

AM Downs, KW Plaxco - ACS sensors, 2022 - ACS Publications
The continuous, real-time measurement of specific molecules in situ in the body would
greatly improve our ability to understand, diagnose, and treat disease. The vast majority of …

Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring

Y Wu, F Tehrani, H Teymourian, J Mack… - Analytical …, 2022 - ACS Publications
The ability to continuously monitor the concentration of specific molecules in the body is a
long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was …

Wearable aptalyzer integrates microneedle and electrochemical sensing for in vivo monitoring of glucose and lactate in live animals

F Bakhshandeh, H Zheng, NG Barra… - Advanced …, 2024 - Wiley Online Library
Continuous monitoring of clinically relevant biomarkers within the interstitial fluid (ISF) using
microneedle (MN)‐based assays, has the potential to transform healthcare. This study …

Rapid and efficient detection of the SARS-CoV-2 spike protein using an electrochemical aptamer-based sensor

A Idili, C Parolo, R Alvarez-Diduk, A Merkoçi - ACS sensors, 2021 - ACS Publications
The availability of sensors able to rapidly detect SARS-CoV-2 directly in biological fluids in a
single step would allow performing massive diagnostic testing to track in real time and …

A review on recent trends and future developments in electrochemical sensing

R Singh, R Gupta, D Bansal, R Bhateria, M Sharma - ACS omega, 2024 - ACS Publications
Electrochemical methods and devices have ignited prodigious interest for sensing and
monitoring. The greatest challenge for science is far from meeting the expectations of …

Aptamer-based point-of-care-testing for small molecule targets: From aptamers to aptasensors, devices and applications

L Zhao, L Li, Y Zhao, C Zhu, R Yang, M Fang… - TrAC Trends in Analytical …, 2023 - Elsevier
Point-of-care testing (POCT) represented the diagnosis performing at or near patient located
site, has extended applications in healthcare, environmental safety, or food quality with low …

Elucidating the mechanisms underlying the signal drift of electrochemical aptamer-based sensors in whole blood

KK Leung, AM Downs, G Ortega, M Kurnik… - ACS …, 2021 - ACS Publications
The ability to monitor drugs, metabolites, hormones, and other biomarkers in situ in the body
would greatly advance both clinical practice and biomedical research. To this end, we are …

Nanoporous gold for the miniaturization of in vivo electrochemical aptamer-based sensors

AM Downs, J Gerson, MN Hossain, K Ploense… - ACS …, 2021 - ACS Publications
Electrochemical aptamer-based sensors enable real-time molecular measurements in the
living body. The spatial resolution of these measurements and ability to perform …

Microneedle electrochemical aptamer-based sensing: Real-time small molecule measurements using sensor-embedded, commercially-available stainless steel …

AM Downs, A Bolotsky, BM Weaver, H Bennett… - Biosensors and …, 2023 - Elsevier
Microneedle sensors could enable minimally-invasive, continuous molecular monitoring–
informing on disease status and treatment in real-time. Wearable sensors for …