Challenges in cardiac tissue engineering

G Vunjak-Novakovic, N Tandon, A Godier… - … Engineering Part B …, 2010 - liebertpub.com
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish
the structure and function of injured myocardium. Engineered constructs can also serve as …

Engineered microenvironments for controlled stem cell differentiation

JA Burdick, G Vunjak-Novakovic - Tissue Engineering Part A, 2009 - liebertpub.com
In a develo** organism, tissues emerge from coordinated sequences of cell renewal,
differentiation, and assembly that are orchestrated by spatial and temporal gradients of …

Accelerated and improved differentiation of retinal organoids from pluripotent stem cells in rotating-wall vessel bioreactors

T DiStefano, HY Chen, C Panebianco, KD Kaya… - Stem cell reports, 2018 - cell.com
Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types
self-patterning into a polarized, laminated architecture. In static cultures, organoid …

Time-and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model

M Haghi, PM Young, D Traini, R Jaiswal… - Drug development …, 2010 - Taylor & Francis
Background: Although standard protocols for the study of drug delivery in the upper airways
using the sub-bronchial epithelial cell line Calu-3 model, particularly that of the air-liquid …

Three-dimensional in vitro tissue culture models of brain organoids

J Gong, T Meng, J Yang, N Hu, H Zhao, T Tian - Experimental neurology, 2021 - Elsevier
Brain organoids are three-dimensional self-assembled structures that are derived from
human induced pluripotent stem cells (hiPSCs). They can recapitulate the spatiotemporal …

[HTML][HTML] Introducing mobile collaborative robots into bioprocessing environments: personalised drug manufacturing and environmental monitoring

R Mathew, R McGee, K Roche, S Warreth… - Applied Sciences, 2022 - mdpi.com
Personalised therapeutic drugs are the future of the medical drug sector. For manufacturers,
this will require the flexibility to produce many different unique batches within a given facility …

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells

G Srinivasan, D Morgan, D Varun, N Brookhouser… - Acta biomaterialia, 2018 - Elsevier
Human pluripotent stem cell derived neural progenitor cells (hNPCs) have the unique
properties of long-term in vitro expansion as well as differentiation into the various neurons …

Bioreactors in tissue engineering

R Obregón, J Ramón‐Azcón… - Tissue Engineering for …, 2017 - Wiley Online Library
This chapter summarizes and discusses the characteristics and applications of all
bioreactors related to tissue engineering (TE). It briefly introduces the different bioreactor …

Kinetic analysis of hybridoma cells viability under mechanical shear stress with and without serum protection

L Legazpi, A Laca, M Díaz - Bioprocess and biosystems engineering, 2009 - Springer
The effect of a well-defined mild shear stress on hybridoma cell viability (HB-8852) in a
serum-free culture medium has been analysed, and the role as shear protector of different …

Stem Cells and Biomaterials: The Tissue Engineering Approach

S Antonini, A Vescovi, F Gelain - Stem Cells & Regenerative Medicine …, 2011 - Springer
Regenerative medicine is an interdisciplinary field of medical science that brings together
the principles of tissue engineering and the life sciences to develop biologic “components” …