Isolated compounds from natural products with potential antidiabetic activity-a systematic review
ACM Munhoz, TS Frode - Current diabetes reviews, 2018 - benthamdirect.com
Background: Worldwide, Type 2 diabetes has become a growing health problem. While
many research articles in the field of ethnopharmacology have focused on the antidiabetic …
many research articles in the field of ethnopharmacology have focused on the antidiabetic …
Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases
Neurodegenerative diseases (NDs) mainly affect neurons and gradually lead to a loss of
normal motor and cognitive functions. Atypical protein homeostasis—misfolding …
normal motor and cognitive functions. Atypical protein homeostasis—misfolding …
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents
This study identified koenidine (4) as a metabolically stable antidiabetic compound, when
evaluated in a rodent type 2 model (leptin receptor-deficient db/db mice), and showed a …
evaluated in a rodent type 2 model (leptin receptor-deficient db/db mice), and showed a …
Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine
Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-
Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian …
Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian …
Transcriptional regulation of glucose metabolism: the emerging role of the HMGA1 chromatin factor
HMGA1 (high mobility group A1) is a nonhistone architectural chromosomal protein that
functions mainly as a dynamic regulator of chromatin structure and gene transcription. As …
functions mainly as a dynamic regulator of chromatin structure and gene transcription. As …
Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and …
In recent years, many alkaloids of plant origin have attracted great attention due to their
diverse range of biological properties including anti-hyperglycemic, anti-oxidant, anti …
diverse range of biological properties including anti-hyperglycemic, anti-oxidant, anti …
Carbazoles: role and functions in fighting diabetes
Carbazole derivatives have gained a lot of attention in medicinal chemistry over the last few
decades due to their wide range of biological and pharmacological properties, including …
decades due to their wide range of biological and pharmacological properties, including …
Anti-diabetic activity of a polyphenol-rich extract from Phellinus igniarius in KK-Ay mice with spontaneous type 2 diabetes mellitus
S Zheng, S Deng, Y Huang, M Huang, P Zhao, X Ma… - Food & function, 2018 - pubs.rsc.org
The present study investigated the anti-diabetic activity and potential mechanisms of the
polyphenol rich extract from Phellinus igniarius (PI-PRE) in vitro and in vivo. Four main …
polyphenol rich extract from Phellinus igniarius (PI-PRE) in vitro and in vivo. Four main …
PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an …
To investigate the role of PTEN (phosphatase and tensin homolog) in mammalian target of
rapamycin complex 2 (mTORC2) signaling in glioblastoma multiforme (GBM), we found …
rapamycin complex 2 (mTORC2) signaling in glioblastoma multiforme (GBM), we found …
Lipid metabolism and body composition in Gclm (−/−) mice
EL Kendig, Y Chen, M Krishan, E Johansson… - Toxicology and applied …, 2011 - Elsevier
In humans and experimental animals, high fat diets (HFD) are associated with risk factors for
metabolic diseases, such as excessive weight gain and adiposity, insulin resistance and …
metabolic diseases, such as excessive weight gain and adiposity, insulin resistance and …