Introduction: Cytokines are a diverse group of peptides produced by different cell types
including cancer cells and various subpopulations of immune system cells. They exert their …

Highlights•Quantitative measurements of 40 proteins or mRNA species per cell.•Antibodies
labeled with isotopes instead of fluorophores.•Deep cell profiling of functional network …

To analyze cellular reprogramming at the single-cell level, mass cytometry was used to
simultaneously measure markers of pluripotency, differentiation, cell-cycle status, and …

Flow cytometry is used increasingly in clinical research for cancer, immunology and
vaccines. Technological advances in cytometry instrumentation are increasing the size and …

Interleukins (ILs)—which are important members of cytokines—consist of a vast group of
molecules, including a wide range of immune mediators that contribute to the immunological …

High-throughput single-cell technologies provide an unprecedented view into cellular
heterogeneity, yet they pose new challenges in data analysis and interpretation. In this …

The immune system has many important regulatory roles in cancer development and
progression. Given the emergence of effective immune therapies against many cancers …

Vaccination is one of the most efficient public healthcare measures to fight infectious
diseases. Nevertheless, the immune mechanisms induced in vivo by vaccination are still …

Cytometry is used extensively in clinical and laboratory settings to diagnose and track cell
subsets in blood and tissue. High-throughput, single-cell approaches leveraging cytometry …

Highlights•Single-cell mass cytometry enables analyses of heterogeneous cell
populations.•Mass-tag cellular barcoding increases multiplexing capability and sample …