[HTML][HTML] Deciphering the tumor microenvironment in prostate cancer: a focus on the stromal component

H Pakula, F Pederzoli, GN Fanelli, PV Nuzzo… - Cancers, 2024 - mdpi.com
Prostate cancer progression is significantly affected by its tumor microenvironment, in which
mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations …

Distinct mesenchymal cell states mediate prostate cancer progression

H Pakula, M Omar, R Carelli, F Pederzoli… - Nature …, 2024 - nature.com
In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their
specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study …

[HTML][HTML] Deciphering Complexity: The Molecular Landscape of Castration-Resistant Prostate Cancer

GN Fanelli, PV Nuzzo, F Pederzoli, M Loda - Surgical Pathology Clinics, 2024 - Elsevier
The transition from castration-sensitive prostate cancer to castration-resistant prostate
cancer (CRPC) and neuroendocrine prostate cancer (NEPC) is a plastic process that …

Peritumoral radiomics strategy based on ensemble learning for the prediction of Gleason Grade Group of Prostate Cancer

Y Qiu, YF Liu, X Shu, XF Qiao, GY Ai, XJ He - Academic Radiology, 2023 - Elsevier
Rationale and Objectives To develop and evaluate a peritumoral radiomic-based machine
learning model to differentiate low-Gleason grade group (L-GGG) and high-GGG (H-GGG) …

Stroma-specific gene expression signature identifies prostate cancer subtype with high recurrence risk

M Rasmussen, J Fredsøe, PV Salachan… - NPJ Precision …, 2024 - nature.com
Current prognostic tools cannot clearly distinguish indolent and aggressive prostate cancer
(PC). We hypothesized that analyzing individual contributions of epithelial and stromal …

Gene Signature for Predicting Metastasis in Prostate Cancer Using Primary Tumor Expression Profiles

I Valencia, PV Nuzzo, E Francini, F Ravera, GN Fanelli… - medRxiv, 2024 - medrxiv.org
Prostate cancer (PCa) is currently the most commonly diagnosed cancer and second
leading cause of cancer-related death in men in the United States. The development of …

Novel intraprostatic MR-guided implantation of multidrug-eluting microdevice for testing of systemic therapy agents in situ; Proof of concept in intermediate-and high …

BV Stone, CA Dominas, SK Bhagavatula… - Journal of …, 2024 - journals.lww.com
Purpose: To assess safety and feasibility of percutaneous MR-guided placement of an
implantable microdevice (IMD) to evaluate in situ intratumor response to multiple …