Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

An enigmatic step in de novo formation of the autophagosome membrane compartment is
the expansion of the precursor membrane phagophore, which requires the acquisition of …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Mammalian cell homeostasis during starvation depends on initiation of autophagy by
endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns (3) P) synthesis …

Healthy cells use autophagy as a general'housekee**'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …