Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Invadopodia are a subset of invadosomes that are implicated in the integration of signals
from the tumor microenvironment to support tumor cell invasion and dissemination. Recent …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms
that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Metastasis requires tumor cell dissemination to different organs from the primary tumor.
Dissemination is a complex cell motility phenomenon that requires the molecular …

The dissemination of cancer cells from the primary tumor to a distant site, known as
metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex …

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological
cancer. Molecular players of ccRCC progression and metastasis are not completely known …

The increasing worldwide prevalence of Hepatocellular carcinoma (HCC), characterized by
resistance to conventional chemotherapy, poor prognosis and eventually mortality, place it …