Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Platinum drugs have been a mainstay of cancer chemotherapy since the introduction of
cisplatin in the 1970s. Since then, carboplatin and oxaliplatin have been approved world …

The development of PtIV prodrugs which are selectively reduced within cancerous cells into
their PtII therapeutically active species has received increasing attention within the last …

Selective activation of Pt (IV) prodrugs within tumors is particularly attractive because of their
low damage to normal tissues. However, current common activation via chemical …

The development of PtIV prodrugs that are reduced into the therapeutically active PtII
species within the tumor microenvironment has received much research interest. In order to …

Despite the great success achieved by photoactivated chemotherapy, eradicating deep
tumors using external sources with high tissue penetration depth remains a challenge. Here …

Combinatorial cancer therapies based on nanomedicine have emerged as a promising
strategy to achieve potentiated treatment efficiency. Herein, cisplatin (CDDP) prodrug (Pt …

Platinum-based anticancer drugs are among the most widely used antineoplastics in clinical
settings. Their therapeutic applications and outcomes are, however, greatly hampered by …

The clinical application of Pt-based anticancer drugs has inspired the development of novel
chemotherapeutic metallodrugs with improved efficacies. Pt (IV) prodrugs are one of the …

In recent years, advancements in microbial sequencing technology have sparked an
increasing interest in the bacteria residing within solid tumors and its distribution and …