Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

The historical roots of Alzheimer's disease provide a sound conceptual basis for linking the
behavioral and neurological symptoms of the disease with the frequently associated …

Whole-chromosome copy number alterations, also known as aneuploidy, are associated
with adverse consequences in most cells and organisms. However, high frequencies of …

De novo copy-number variants (CNVs) can cause neuropsychiatric disease, but the degree
to which they occur somatically, and during development, is unknown. Single-cell whole …

Results To follow the fate of live cells that missegregate chromosomes, we generated
HCT116 cells that expressed LacIGFP and had multiple copies of lacO integrated into a …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

Mobile elements are DNA sequences that can change their position (retrotranspose) within
the genome. Although its biological function is largely unappreciated, DNA derived from …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date,
aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also …