The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
Cytokine-induced killer cells as pharmacological tools for cancer immunotherapy
X Gao, Y Mi, NA Guo, H Xu, L Xu, X Gou… - Frontiers in …, 2017 - frontiersin.org
Cytokine-induced killer (CIK) cells are a heterogeneous population of effector CD3+ CD56+
natural killer T cells, which can be easily expanded in vitro from peripheral blood …
natural killer T cells, which can be easily expanded in vitro from peripheral blood …
Extra-large pore mesoporous silica nanoparticles enabling co-delivery of high amounts of protein antigen and toll-like receptor 9 agonist for enhanced cancer vaccine …
Cancer vaccine aims to invoke antitumor adaptive immune responses to detect and
eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have …
eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have …
[HTML][HTML] Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma
M Shi, B Zhang, ZR Tang, ZY Lei, HF Wang… - World journal of …, 2004 - ncbi.nlm.nih.gov
AIM: To investigate the influence of autologous cytokine-induced killer (CIK) cells on the
phenotypes of CIK effector cells, peripheral T lymphocyte subsets and dendritic cell subsets …
phenotypes of CIK effector cells, peripheral T lymphocyte subsets and dendritic cell subsets …
Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
Abstract CD3+ CD56+ cytokine-induced killer (CIK) cells display a potent cytolytic activity.
The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in …
The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in …
Interleukin-2 therapy of cancer-clinical perspectives
J Majidpoor, K Mortezaee - International immunopharmacology, 2021 - Elsevier
Abstract Interleukin (IL)-2 is a pleiotropic cytokine that displays opposing activities on
immune system acting either in favor of or against cancer progression. Advanced/metastatic …
immune system acting either in favor of or against cancer progression. Advanced/metastatic …
Targeting PD-1 and Tim-3 pathways to reverse CD8 T-cell exhaustion and enhance ex vivo T-cell responses to autologous dendritic/tumor vaccines
J Liu, S Zhang, Y Hu, Z Yang, J Li, X Liu… - Journal of …, 2016 - journals.lww.com
The paradoxical coexistence of spontaneous tumor antigen-specific immune response with
progressive disease in cancer patients need to dissect the molecular pathways involved in …
progressive disease in cancer patients need to dissect the molecular pathways involved in …
Enhanced antitumor effects of DC-activated CIKs to chemotherapy treatment in a single cohort of advanced non-small-cell lung cancer patients
L Yang, B Ren, H Li, J Yu, S Cao, X Hao… - Cancer immunology …, 2013 - Springer
Cytokine-induced killer (CIK) cells show cytolytic activity against tumor. The purpose of this
study was to evaluate the antitumor effect of dendritic cell (DC)-activated CIK cells in vitro …
study was to evaluate the antitumor effect of dendritic cell (DC)-activated CIK cells in vitro …
Cytokine-induced killer cells: NK-like T cells with cytotolytic specificity against leukemia
Cytokine-induced killer (CIK) cells are a unique population of cytotoxic T lymphocytes (CTL)
with the characteristic CD3+ CD56+ phenotype. These cells have demonstrated higher …
with the characteristic CD3+ CD56+ phenotype. These cells have demonstrated higher …
Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery
H Li, C Wang, J Yu, S Cao, F Wei, W Zhang, Y Han… - …, 2009 - Taylor & Francis
Background aims Cytokine-induced killer (CIK) cells have shown cytolytic activity against
several tumor cells in vitro and in animal tumor models. Furthermore, CIK cells activated by …
several tumor cells in vitro and in animal tumor models. Furthermore, CIK cells activated by …