Engineering 3D hydrogels for personalized in vitro human tissue models

CY Liaw, S Ji, M Guvendiren - Advanced healthcare materials, 2018 - Wiley Online Library
There is a growing interest in engineering hydrogels for 3D tissue and disease models. The
major motivation is to better mimic the physiological microenvironment of the disease and …

Emerging technologies for pulmonary vein isolation

FD Ramirez, VY Reddy, R Viswanathan… - Circulation …, 2020 - ahajournals.org
Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with
considerable morbidity and mortality. Electrically isolating the pulmonary veins from the left …

Selective modulation of intracellular effects of cells using pulsed electric fields

MB Sano, B Christopher, SS Verbridge… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
54480565&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Dynamics of cell death after conventional IRE and H-FIRE treatments

B Mercadal, N Beitel-White, KN Aycock… - Annals of biomedical …, 2020 - Springer
High-frequency irreversible electroporation (H-FIRE) has emerged as an alternative to
conventional irreversible electroporation (IRE) to overcome the issues associated with …

In vitro cell selectivity of reversible and irreversible: electroporation in cardiac tissue

DW Hunter, G Kostecki, JM Fish… - Circulation: Arrhythmia …, 2021 - ahajournals.org
Background: Pulmonary vein isolation is a common catheter ablation technique used to treat
atrial fibrillation originating from the pulmonary veins. However, incomplete lesion formation …

System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress

IIR Neal, RV Davalos - US Patent 10,238,447, 2019 - Google Patents
(Continued) Primary Examiner—Michael F Peffley (74) Attorney, Agent, or Firm—New River
Valley IP Law, PC; Michele L. Mayberry (57) ABSTRACT A medical system for ablating a …

Bursts of bipolar microsecond pulses inhibit tumor growth

MB Sano, CB Arena, KR Bittleman, MR DeWitt… - Scientific reports, 2015 - nature.com
Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility
in the treatment of unresectable tumors where thermal ablation techniques are …

Device and method for electroporation based treatment of stenosis of a tubular body part

IIRE Neal, PA Garcia, RV Davalos, P Callas - US Patent 10,702,326, 2020 - Google Patents
The present invention relates to medical devices and meth ods for treating a lesion such as
a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodi ments of …

In-vitro bipolar nano-and microsecond electro-pulse bursts for irreversible electroporation therapies

MB Sano, CB Arena, MR DeWitt, D Saur, RV Davalos - Bioelectrochemistry, 2014 - Elsevier
Under the influence of external electric fields, cells experience a rapid potential buildup
across the cell membrane. Above a critical threshold of electric field strength, permanent cell …

Targeted cellular ablation based on the morphology of malignant cells

JW Ivey, EL Latouche, MB Sano, JH Rossmeisl… - Scientific reports, 2015 - nature.com
Abstract Treatment of glioblastoma multiforme (GBM) is especially challenging due to a
shortage of methods to preferentially target diffuse infiltrative cells and therapy-resistant …