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Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Antimalarial drug resistance and implications for the WHO global technical strategy
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
Evolution of partial resistance to artemisinins in malaria parasites in Uganda
MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …
component of artemisinin-based combination therapies, the most important malaria drugs …
Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia
AA Fola, SM Feleke, H Mohammed, BG Brhane… - Nature …, 2023 - nature.com
Diagnosis and treatment of Plasmodium falciparum infections are required for effective
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …
Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia
SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania
Zanzibar has made significant progress toward malaria elimination, but recent stagnation
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …
Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana
ST Girgis, E Adika, FE Nenyewodey… - Nature …, 2023 - nature.com
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …
children living in sub-Saharan Africa. Molecular surveillance can provide important …
Malaria protection due to sickle haemoglobin depends on parasite genotype
G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …
this has led to evolutionary adaptation of parasite populations. Here we searched for …