Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Evolution of partial resistance to artemisinins in malaria parasites in Uganda

MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …

Antimalarial drug resistance and implications for the WHO global technical strategy

MM Ippolito, KA Moser, JBB Kabuya… - Current epidemiology …, 2021 - Springer
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

AA Fola, SM Feleke, H Mohammed, BG Brhane… - Nature …, 2023 - nature.com
Diagnosis and treatment of Plasmodium falciparum infections are required for effective
malaria control and are pre-requisites for malaria elimination efforts; hence we need to …

Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda

V Asua, MD Conrad, O Aydemir… - The Journal of …, 2021 - academic.oup.com
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia

SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

PK Tumwebaze, MD Conrad, M Okitwi, S Orena… - Nature …, 2022 - nature.com
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Malaria protection due to sickle haemoglobin depends on parasite genotype

G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Molecular markers for malaria genetic epidemiology: progress and pitfalls

S Ruybal-Pesántez, K McCann, J Vibin, S Siegel… - Trends in …, 2024 - cell.com
Over recent years, progress in molecular markers for genoty** malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

ST Girgis, E Adika, FE Nenyewodey… - Nature …, 2023 - nature.com
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …