The Mediator complex as a master regulator of transcription by RNA polymerase II
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
[HTML][HTML] The self-organizing genome: principles of genome architecture and function
T Misteli - Cell, 2020 - cell.com
Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …
genetic, biochemical, biophysical, and cell biological methods has uncovered several …
Mechanisms of enhancer action: the known and the unknown
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
[HTML][HTML] “Structure”-function relationships in eukaryotic transcription factors: the role of intrinsically disordered regions in gene regulation
Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
[HTML][HTML] Structure and mechanism of the RNA polymerase II transcription machinery
AC Schier, DJ Taatjes - Genes & development, 2020 - genesdev.cshlp.org
Abstract RNA polymerase II (Pol II) transcribes all protein-coding genes and many
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …
noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it …
Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Transcription in living cells: molecular mechanisms of bursting
Transcription in several organisms from certain bacteria to humans has been observed to be
stochastic in nature: toggling between active and inactive states. Periods of active nascent …
stochastic in nature: toggling between active and inactive states. Periods of active nascent …
What is a transcriptional burst?
E Tunnacliffe, JR Chubb - Trends in Genetics, 2020 - cell.com
The idea that gene activity can be discontinuous will not surprise many biologists–many
genes are restricted in when and where they can be expressed. Yet during the past 15 …
genes are restricted in when and where they can be expressed. Yet during the past 15 …
Transcription factor dynamics: one molecule at a time
Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …
biochemical and biophysical cues within their environment. This information is transmitted to …
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs
within the local chromatin context. The mechanisms by which TFs navigate the nuclear …
within the local chromatin context. The mechanisms by which TFs navigate the nuclear …