Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype
to treat. To date, therapies directed to specific molecular targets have rarely achieved …

In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell …

Patterns of genomic evolution between primary and metastatic breast cancer have not been
studied in large numbers, despite patients with metastatic breast cancer having dismal …

Metastatic cancer is a major cause of death and remains largely incurable. A better
understanding of metastasis is therefore desperately needed to improve prognosis for late …

Rational development of targeted therapies has revolutionized metastatic breast cancer
outcomes, although resistance to treatment remains a major challenge. Advances in …

Purpose Cell-free DNA (cfDNA) offers the potential for minimally invasive genome-wide
profiling of tumor alterations without tumor biopsy and may be associated with patient …

Metastasis is an evolutionary process occurring across multiple organs and timescales. Due
to its continuous and dynamic nature, this multifaceted process has been challenging to …