The extracellular matrix in tumor progression and metastasis
JA Eble, S Niland - Clinical & experimental metastasis, 2019 - Springer
The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …
network of extracellular proteins, proteoglycans and glycoproteins, which form …
Broken detailed balance and non-equilibrium dynamics in living systems: a review
FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …
Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress
Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
H Wu, Y Shen, S Sivagurunathan… - Proceedings of the …, 2022 - National Acad Sciences
The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …
proteins, F-actin, microtubules, and intermediate filaments. Interactions among the …
Front–rear polarization by mechanical cues: from single cells to tissues
Directed cell migration is a complex process that involves front–rear polarization,
characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and …
characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and …
Mechanotransduction by the actin cytoskeleton: converting mechanical stimuli into biochemical signals
Force transmission through the actin cytoskeleton plays a central role in cell movements,
shape change, and internal organization. Dynamic reorganization of actin filaments by an …
shape change, and internal organization. Dynamic reorganization of actin filaments by an …
Mechanoaccumulative elements of the mammalian actin cytoskeleton
To change shape, divide, form junctions, and migrate, cells reorganize their cytoskeletons in
response to changing mechanical environments [1–4]. Actin cytoskeletal elements, including …
response to changing mechanical environments [1–4]. Actin cytoskeletal elements, including …
Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds
Integrin-based adhesion complexes link the cytoskeleton to the extracellular matrix (ECM)
and are central to the construction of multicellular animal tissues. How biological function …
and are central to the construction of multicellular animal tissues. How biological function …
The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer
K Honda - Cell & bioscience, 2015 - Springer
Invasion and metastasis are malignant phenotypes in cancer that lead to patient death. Cell
motility is involved in these processes. In 1998, we identified overexpression of the actin …
motility is involved in these processes. In 1998, we identified overexpression of the actin …
Volumetric compression for engineering living systems
Life, as a dense manifestation of soft matter, undergoes changes in water content,
biomacromolecular concentrations, condensation and crowding due to volumetric …
biomacromolecular concentrations, condensation and crowding due to volumetric …