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Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution
Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …
Concise review of the glutathione S-transferase and their significance to toxicology.
The article discusses the major features of the glutathione S-transferases (GST), a multi-
gene family of enzymes involved in the detoxification or activation of a wide variety of …
gene family of enzymes involved in the detoxification or activation of a wide variety of …
The impact of stress on the development and expression of atopy
Current Opinion in Allergy and Clinical Immunology Log in or Register Subscribe to journalSubscribe
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Human cytosolic glutathione transferases: structure, function, and drug discovery
Glutathione transferases (GSTs) are important detoxifying enzymes that catalyze the
conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of …
conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of …
Glutathione S-transferases: an overview in cancer research
Importance of the field: The Glutathione S-transferases (GSTs) have advanced beyond the
classic view of their role in metabolism and are encouraging scientists to assess new …
classic view of their role in metabolism and are encouraging scientists to assess new …
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
K Sundberg, AS Johansson, G Stenberg… - …, 1998 - academic.oup.com
Previous studies have identified allelic variants of the human glutathione transferase (GST)
Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) …
Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) …
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility
It has become clear that several polymorphisms of human drug-metabolizing enzymes
influence an individual's susceptibility for chemical carcinogenesis. This review gives an …
influence an individual's susceptibility for chemical carcinogenesis. This review gives an …
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high‐risk population
Tobacco smoking and occupation are major risk factors of bladder cancer via exposure to
polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Glutathione s‐transferase …
polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Glutathione s‐transferase …
Genetic polymorphisms in oxidative stress and inflammatory pathways as potential biomarkers in Alzheimer's disease and dementia
D Vogrinc, M Gregorič Kramberger, A Emeršič… - Antioxidants, 2023 - mdpi.com
Oxidative stress and neuroinflammation are important processes involved in Alzheimer's
disease (AD) and mild cognitive impairment (MCI). Numerous risk factors, including genetic …
disease (AD) and mild cognitive impairment (MCI). Numerous risk factors, including genetic …