At present, bone nonunion and delayed union are still difficult problems in orthopaedics.
Since the discovery of bone morphogenetic protein (BMP), it has been widely used in …

Critical bone defects and related delayed union and nonunion are still worldwide problems
to be solved. Bone tissue engineering is mainly aimed at achieving satisfactory bone …

The clinical standard therapy for large bone defects, typically addressed through autograft or
allograft donor tissue, faces significant limitations. Tissue engineering offers a promising …

Emerging additive manufacturing (AM) strategies can enable the engineering of hierarchal
scaffold structures for guiding tissue regeneration. Here, the advantages of two AM …

Exposure to a growth factor abundant milieu has remarkable regenerative and rejuvenating
effects on organ diseases, tissue damage, and regeneration, including skeletal system …

Large bone defects resulting from trauma, infection and tumors are usually difficult for the
body's repair mechanisms to heal spontaneously. Generally, various types of bones and …

Bone defect repair caused by trauma, congenital malformation, tumors, infection or systemic
diseases remains the focus of attention in regeneration medicine. Recent advances in …

Bone tissue engineering, as an important and attractive multidisciplinary field, affords a
feasible strategy for large bone defects which are difficult to heal without clinical intervention …

Cell–material interactions are regulated by mimicking bone extracellular matrix on the
surface of biomaterials. In this regard, reproducing the extracellular conditions that promote …

BACKGROUND: Tissue engineering approaches to treat damaged bone include various
tissue transplants such as autologous, allogeneic, and xenografts. Artificial materials have …