Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

Pain on injection of propofol is a common problem, the cause of which remains unknown.
The chemical properties and preparation of propofol, proposed mechanisms for the cause of …

Department of Anaesthesia, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon
Tyne NE1 4LP, UKThe use of propofol infusions to sedate children in intensive care units …

Data on seizure-like phenomena (SLP) in patients receiving propofol were systematically
reviewed. Reports had to provide detailed information on SLP in individual patients who …

Although questions may still remain regarding the use of this unique sedative-hypnotic drug
with anesthetic properties in highrisk patients, these studies have provided cardiopulmonary …

Children require higher infusion rates of propofol than adults to maintain clinical
anaesthesia. We aimed to produce a manual infusion regimen capable of maintaining a …

We studied the hemodynamic effects of propofol during elective cardiac catheterization in 30
children with congenital heart disease. Sixteen patients were without cardiac shunt (Group …

Background No complete pharmacokinetic profile of propofol is yet available in children
younger than 3 yr, whereas clinical studies have demonstrated that both induction and …

In a single‐blind study of 100 children aged 1 to 10 years, the minimum effective dose of
lignocaine required to prevent injection pain due to propofol was 0.2 mg. kg− 1 when veins …

The article discusses the debate on the use of total intravenous anesthesia (TIVA) and
inhalation anesthesia. The arguments for TIVA's use in pediatrics was presented by Martin …