Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Apoptosis is a sequential order of cell death occurring regularly to ensure a homeostatic
balance between the rate of cell formation and cell death. However, a misplaced of this …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Suppression of apoptosis by expression of antiapoptotic BCL2 family members is a hallmark
of acute myeloblastic leukemia (AML). Induced myeloid leukemia cell differentiation protein …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

The calcium ion has long been known to play an important role in cell death regulation.
Hence, necrotic cell death was early associated with intracellular Ca 2+ overload, leading to …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

The Bcl-2 family of proteins controls a critical step in commitment to apoptosis by regulating
permeabilization of the mitochondrial outer membrane (MOM). The family is divided into …