Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …

Th17 cells play an important physiological role at mucosal barriers, and are involved in
inflammatory responses to pathogens. Th17 cells and their signature cytokine IL-17 are also …

Current Opinion in Ophthalmology Log in or Register Get new issue alertsGet alerts
Subscribe to journal Secondary Logo Journal Logo Advanced Search Toggle navigation …

Primary Sjögren syndrome is an autoimmune disease that mainly affects exocrine glands
such as the salivary and lacrimal glands. In addition, systemic involvement is common …

Sjogren's syndrome (SS) is a slowly progressing autoimmune disease, affecting
predominantly middle-aged women, with a female to male ratio reaching 9: 1. It is …

Inflammation is a defensive process against tissue injury. Once this self‐protective strategy
is initiated, an effective resolution of the process is crucial to avoid major and unnecessary …

Immune regulation by cytokines is crucial in maintaining immune homeostasis, promoting
responses to infection, resolving inflammation, and promoting immunological memory …

Dry eye is an inflammatory disease that results from activation of innate inflammatory
pathways in resident ocular surface cells, as well as cytokines produced by recruited T …