Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

The concept of induced protein degradation by small molecules has emerged as a
promising therapeutic strategy that is particularly effective in targeting proteins previously …

Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome
also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is …

Cells maintain optimal levels of lysosome degradative activity to protect against pathogens,
clear waste, and generate nutrients. Here, we show that LRRK2, a protein that is tightly …

Translocation renal cell carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3
fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we …

The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3,
MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject …

Perivascular epithelioid cell neoplasms (PEComas) are tumors of uncertain cell lineage that
occur across a wide age range, at a variety of anatomic sites, and with a female …

Reversible phosphorylation is a fundamental mechanism for controlling protein function.
Despite the critical roles phosphorylated proteins play in physiology and disease, our ability …

Controlled protein degradation by the ubiquitin‐proteasome pathway is critical for almost all
cellular processes. E3 ubiquitin ligases are responsible for targeting proteins for …

During mouse preimplantation development, a subset of retrotransposons/genes are
transiently expressed in the totipotent 2-cell (2C) embryos. These 2C transcripts rapidly shut …